It has some encouraging results to use ozone in medicaments, treatments and so on. As it is usually in gas state, unstable and strong oxidability, ozone is difficult to be stored and used commonly. It is the key matter in use of ozone commonly or conveniently that the carrier material and preparation response conditions are studied to make the bond strength between ozone and carrier to be felicitous and with the proper velocity to release ozone from the ozonic compound. Ozonic compound and related single molecules were calculated to study the interaction between ozone and carrier to form ozonic compound. The carrier and ozonic compound are designed from the calculations. The stability of the ozonic compound, or the bond strength between ozone and carrier are controlled felicitously to release ozone from the ozonic compound with proper velocity. Ozone antimicrobial can be composed and used conveniently, especially for common families. There are some characteristics of ozone antimicrobial or ozone, such as universal applicability, efficiency and rapidity, security, strong penetrability, no drug resistance and sterilization and treatment simultaneity.