Paper Title:
Preparation of β-Cyclodextrin Modified Poly(d,l-Lactic Acid) and its Blood Compatibility
  Abstract

Aiming to develop a biomaterial with excellent biocompability, a novel β-cyclodextrin modified polylactic acid (PLA-β-CD) was synthesized by N-acylation reaction of MPLA (maleic anhydride modified poly(d,l-lactic acid)) using hydrophilic mono(6-(2-aminoethyl)-amino-6-deoxy)- β-cyclodextrin(β-CD-6-E) as acylating agent. Surface wettability and blood biocompatibility of PLA-β-CD were investigated. The tests indicated that the static water contact angle of PLA-β-CD was decreased from 76.7º to 72.1º comparing with PLA. The morphology of blood platelets adhered on the surface of PLA-β-CD was observed by scanning, and only a few platelets, round and not aggregated. The results revealed that the blood compatibility of PLA-β-CD was better than PLA.

  Info
Periodical
Advanced Materials Research (Volumes 181-182)
Edited by
Qi Luo and Yuanzhi Wang
Pages
429-433
DOI
10.4028/www.scientific.net/AMR.181-182.429
Citation
J. J. Zhu, X. J. Quan, Y. L. Wang, S. S. Zou, "Preparation of β-Cyclodextrin Modified Poly(d,l-Lactic Acid) and its Blood Compatibility", Advanced Materials Research, Vols. 181-182, pp. 429-433, 2011
Online since
January 2011
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Price
$32.00
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