Paper Title:
Study of Esculetin-Induced Apoptosis in Human Gastric Carcinoma SGC-7901 Cells
  Abstract

In order to investigate the effect and its mechanism of esculetin on human gastric carcinoma SGC-7901 cells, the effect of esculetin on human gastric carcinoma SGC-7901 cells were investigated by MTT method in vitro studies. Then the morphological feature changes of apoptosis cells with esculetin of different concentration by transmission electron microscope were observed and the levels of Cty-c in SGC-7901 cells line using FCM method were analyzed. The results revealed that the Esculetin significantly inhibited the growth of human gastric carcinoma SGC-7901 cells and greatly decreased its growth rate with the esculetin concentration increased, and then the morphological feature changes of apoptosis cells had been observed. After 24h, esculetin could make that the concentration of Cty-c in endochylema and Caspase-3 were all increased. Thus the study showed that esculetin remarkably inhibited the growth of human gastric carcinoma SGC-7901 cells and induce its apoptosis.

  Info
Periodical
Advanced Materials Research (Volumes 183-185)
Edited by
Yanguo Shi and Jinlong Zuo
Pages
2336-2339
DOI
10.4028/www.scientific.net/AMR.183-185.2336
Citation
S. H. Jia, Y. B. Ji, "Study of Esculetin-Induced Apoptosis in Human Gastric Carcinoma SGC-7901 Cells", Advanced Materials Research, Vols. 183-185, pp. 2336-2339, 2011
Online since
January 2011
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Price
$32.00
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