In modern machining processes, Gantry Machining Center is one of the most important machine tools. Moreover, beam components directly relate to the overall performance. From multi-body simulation (MBS) and finite element analysis (FEA) respectively, the paper discusses current state of the multi-body dynamics modelling of the machine tool components in domestic and overseas. In this paper, We adopt a method, the multi-flexible body dynamics(MFBD) modeling method for machine tool transmission components (linear guidance and ball screw drives) in software Recurdyn, to create the conditions for MFBD simulation analysis of the beam components system. Much more, it provides a way of MFBD modelling for machine tools components in both the high-speed and high-performance.