The influence of process conditions on the formability of injection-molded PX0034 (9% talc-filled PP) automobile B column mounting trim applied as a model has been studied in current work. This study has been focused on the interactive influence of melt temperature and mold temperature, the interactive influences of injection time and packing time and the influences of packing pressure. Weighting the effect of optimization is by formability including the values of pressure at V/P switchover, volumetric shrinkage differential at ejection, and maximum warpage. Aforementioned values were obtained by numerical simulation of the whole molding process using commercial dedicated code Moldflow. Results indicate that the combination of mold temperature at 25 °C, melt temperature at 220 °C, injection time at 2.2 s, packing time at 16 s and packing pressure at 90% of the filling pressure is the optimal setting for formability of this trim. The simulation results obtained under the optimized parameters are that the pressure at V/P switchover is 27.29 Mpa, the shrinkage differential at ejection is 6.55 %, and maximum warpage is 3.072 mm. Good correlation is highlighted between the experiments and the simulations by comparing effects of the global optimization in formability, which verifies the validity of the optimal combination.