For the large and complicated injection mold, the deformation of mold is one of the important factors to affect the plastic part quality and mold life. However, the accurate prediction of mold deformation is usually difficult because of the no-matching mesh between the part molding analysis and the mold structural analysis. Their analysis results can not be directly imported mutually, which leads to the loading of boundary condition having much obstacles in integrated analysis. To conquer the problem, this paper researches and develops an injection molding simulation system(Z-mold) based on Hele-shaw model, and establishes the data share interface between Z-mold and ANSYS by means of uniform mesh. Based on these studies, this paper carries out the integrated analysis of injection molding and mold. The deformation of mold under the load of the real molding pressure is successfully predicted, which is more accurate than the estimation by use of the empirical formula. This paper’s integrated study possesses great application value.