Mining from the equipment/technology process historical data can find diagnosis knowledge. Real-time analysis and evaluation on the status of equipment can be realized based on its current state parameters and historical information, which detect the potential fault rapidly and protect equipment to avoid failures further. This paper did an in-depth study in real-time data-based fault diagnosis system, built a real-time data integration platform and accomplished intelligent diagnosis method by ANFIS networks with the mined historical data. The production process was diagnosed and evaluated online with this diagnosis method. Combined with actual production system, its prototype system was developed.