Laser shock processing (LSP) is a new technique for surface strengthening of fastener holes. The process of LSP before hole-drilling was adopted. A finite element model was established to study the effects of laser shock parameters on the residual stress field of aluminum alloy7050T7451 with Fastener Holes. The results indicate that increasing the laser power density until a fixed value results in a large peak in the hole-edge surface residual compressive stress. The hole-edge surface residual compressive stress and the depth of residual compressive stress are both increased with the increase of laser pulse width. Multiple laser shock processing can improve the residual compressive stress greatly, and with the increasing number of shot, the strengthening effect is gradually diminished.