This paper studied the effects of inclusion and slag on properties of a die cast A356 alloy wheel. The result showed that the rate of defect is important for the mechanical properties. The tensile strength and extension was not dropped but the rate of defect is increased about 2%. The variation trend of tensile strength and extension is linear, while the area of porosity on tensile fracture is between 2% and 6%. However, the tensile strength and extension was dropped with the increasing rate of defect. The variation trend of mechanical properties of the sample with inclusion is stable, but the sample with slag is not stable. The mechanical properties of samples with inclusion are drastically changed, while the rate of defect is increased. The mechanical properties of samples with slag are smoothly. The EDS analysis indicated that the defects consist of Al-Ti-B compound, α-phase (Al12FeSi), β-phase (Al9Fe2Si2) and Al2O3. These oxides form the compact composite oxide film expand into first cracks. The fracture mode of sample with defects is brittle fracture. The values of the Secondary dendrite arm spacing (DAS) in the inclusion and the matrix are the same, while the values of DAS in the slag and the matrix are different.