Paper Title:
Formulation and Evaluation of Isosorbide Dinitrate Acrylic Matrix Transdermal Patches
  Abstract

The aim of this study was to prepare and investigate the isosorbide dinitrate transdermal patches (IDPs) in the concentration of 40 mg/cm2. Acrylic pressure sensitive adhesives (PSA) were used to formulate IDPs. IDPs were prepared by casting method. The effect of content of PSA, and concentration of enhancer, propylene glycol, in the formulations were evaluated. IDPs were investigated for their thickness, weight/area ratio, adhesiveness and in vitro skin permeation. The higher the content of PSA in the formulation, the higher the thickness and the W/A ratio. Propylene glycol added in the formulation (2.5, 5, 10%) significantly enhanced the skin permeation of ISDN. The higher the content of PG, the higher the flux of ISDN through the skin. Our research suggests that isosorbide dinitrate loaded with 10% of propylene glycol in acrylic matrix pressure sensitive adhesive can be potentially used as a transdermal drug delivery system.

  Info
Periodical
Advanced Materials Research (Volumes 197-198)
Edited by
Huaiying Zhou, Tianlong Gu, Daoguo Yang, Zhengyi Jiang, Jianmin Zeng
Pages
1217-1220
DOI
10.4028/www.scientific.net/AMR.197-198.1217
Citation
P. Jarenputtakrun, P. Opanasopit, S. Panomsuk, T. Ngawhirunpat, "Formulation and Evaluation of Isosorbide Dinitrate Acrylic Matrix Transdermal Patches", Advanced Materials Research, Vols. 197-198, pp. 1217-1220, 2011
Online since
February 2011
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Price
$32.00
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