The need for a topical drug delivery system of griseofulvin (GF) is dued to its poor oral bioavailability because of its low water solubility and excessively side effects. The preparation of griseofulvin-loaded into solid lipid nanoparticles (GF-SLNs) to nanometer range is expected to improve the dissolution rate by increasing the specific surface area. The aim of investigation was to produce griseofulvin-loaded into solid lipid nanoparticles by using a simple microemulsion technique, using glyceryl monostearate as solid lipid, polysorbate 20 as emulsifier, butanol and Transcutol HP®as co-emulsifiers. The GF-SLNs were evaluated for physical and chemical properties including GF release from GF-SLNs. The spherical particles were observed by TEM. The mean particle size of GF-SLNs was 165 nm and the zeta potential of GF-SLNs was -36 mV. There were interactions between GF and excipients in formula. The GF releasing profiles were obtained by a dialysis method with pH 5.5 phosphate buffer as medium, the release profile of GF was to be a prolong release of 63.53% within 12 hours.