A MoS2/TiO2 composite was synthesized and its photocatalytic activity for the degradation of methylene blue was evaluated. The results showed that the nano-MoS2/TiO2 composite presented excellent photocatalytic properties in the degradation reaction of methylene blue, which was ascribed to the good absorption of nano-MoS2/TiO2 in the visible light region. The decoloration rate of methylene blue solution was influenced by the dosage of nano-MoS2/TiO2 and the initial concentration of methylene blue. However, both the pH value and the degradation temperature had negligible effects on the decoloration rate of methylene blue. Moreover, the nano-MoS2/TiO2 composite as the degradation catalyst of methylene blue was of good regeneration properties.