Hydraulic press is important pressure processing equipment, which has a wide range of applications in production and manufacturing industry. The structure of hydraulic press frame has an extremely significant effect on safety and usability. Against the structure of frame-type hydraulic press in this paper, a solid model has been built with CAD program Pro/E and the hydraulic press frame under working conditions is simulated by finite element simulation program ANSYS. This paper analyses the variation of stress, strain and frame deformation under working conditions, and the dangerous sections of hydraulic press frame can be found under the maximum work load. The research results show: The maximum value of effective strain and effective stress can be found in the screw holes of cylinder port, the maximum value of stress and strain in the direction of hydrocylinder force can be found in the confluence of upright column and lower beam, the maximum value of effective displacement and the displacement in the direction of hydrocylinder force can be found in cylinder port and part of upper beam.