In modern manufacturing industry, there are a great deal of micro inclined holes, which is a difficult problem to machining. A novel micro inclined hole drilling method, step vibration drilling, is adopted. The experiments are carried that 45 degrees inclined hole is drilled into the 45 steel workpiece with Φ0.5mm carbide drill bit. The notable result was obtained with the method of step vibration drilling for drilling 45 degrees inclined holes on 45 steel, which break the restriction of drill jig. The new approach is put forward for micro inclined hole.