Piles and dumps in mining sites of lignite and ore mines very often generate drainage water with a low pH value. Furthermore they are contaminated with heavy metals or radionuclides. A comprehensive sustainable remediation and / or a water treatment process requires an assessment of the water quality and the determination of the future development thereof. This, in turn, requires prediction of the microbial processes which are responsible for the release of heavy metals and radionuclides. The paper deals with the demonstration of a suitable method for the prediction of these reactions and water quality.