The manufacturing industry must have manufacturing systems that deal with the agile response to the appearance and changing conditions.As biological organisms are quite capable of adapting to environmental changes and stimulus, bio-inspired concepts have been recognized much suitable for adaptive manufacturing system control. This paper, therefore, proposes a NeuroEndocrine-Inspired Manufacturing System (NEIMS) using the potential field concept. The proposed NEIMS control architecture is inherited from neuro-control and hormone-regulation principles to agilely deal with the frequent occurrence of unexpected disturbances at the shop floor level. Hormone-regulation can impel system to be equilibrium through a potential field approach. From the cybernetics point of view, the control model of NEIMS has been described in detail. And a test bed has been set up to enable the NEIMS simulation.