A method for continuous box-girder bridge structure finite element (FE) model updating based on static-load testing is proposed. The procedure includes field static-load testing, FE modeling, FE model (parameter) updating, etc. Based on this procedure, the structure FE model updating for an expressway 5-span pre-stressed concrete continuous box-girder bridge is conducted. And the bridge structure static FE model, which is consistent with the static-load testing actual measure response, is gained. The updated FE model (parameter) is foundation of structural performance evaluation for the bridge.