SNCR (Selective Non Catalytic Reduction) system is proposed, with 40% methylamine aqueous solution as reducing agent to reduce NOx in diesel exhaust gas. The effect of injection position and volume on the reduction efficiency through the test bench is systematically researched. A three-dimensional model of a full-sized diesel SNCR system generated by CFD software FIRE is used to investigate the reduction efficiency under different temperatures. The simulated results have a good agreement with the test results, and it can be used to optimize SNCR system. The results can indicate the practical application of this technology.