This study aimed to perform a case study of the artworks colored using mixed media by applying qualitative methods. The teacher and the students wrote the story and completed the storyboard through interactive discussion teaching. With the knowledge of the properties of current painting papers and media used for coloring, the teacher was able to guide the students to choose paper of better quality, and select proper mixed media to create their artworks, so that the picture book could be richer and more delicate. Furthermore, documentary analysis was performed with current documents related to picture books to provide the students references for their artworks. Finally, the students were guided to process their graphs and arrange the layout using computer software, to complete a picture book artwork colored using mixed media by both hand-drawing and computer graphing and this study.