Considering the demands for product ergonomics design, the paper proposed a driven design method for product’s shape and structure design through the manipulation of human body models. Based on the anthropometry data, a parametric human body driving model system is established with three layers, which are structure model, dimension model and surface model. The driven design method of product ergonomics design is realized, in which human body data are directly mapped to product design parameters. The driven design method provides a rational way to utilize ergonomics design principles and guarantee higher efficiency and more reliability. The method is tested in seat design examples.