In this paper, mixed mode stress intensity factor (SIF) solutions are computed for inclined surface cracks in finite-thickness plates. The S-version finite element method (S-FEM), which is an adaptive method and multi-scale computing method, are employed in the analyses. When S-FEM is applied to solve the fracture problem, local mesh model including cracks can be built independently from the global mesh model for modeling overall structure. The local model is superposed on the g- lobal one. Therefore, it is easy to introduce cracks in an existing mesh model. The influences of inc- lination angles, crack shape and plate thickness on the mixed mode fracture solution were investiga- ted. The solutions presented can be used to assess fail/safe conditions and fatigue crack growth for the three-dimensional cracks studied.