In this paper, large scale wind turbine blade has been taken for example and two harmful conditions have been chosen as the study targets. Taking a 25 m long wind turbine blade, its solid model is built in CAE. Then take advantage of Computational Fluid Dynamics software-FLUENT to analyze and simulate wind pressure of blade surface acted by aerodynamic force. By means of the numerical method to make curve fitting to bring wind pressure to bear on each cross section of blade accurately, and import it into ANSYS to do further analytical work. It shows that the work should be the firm foundation for further analysis of the wind turbine blade.