As large-scale enterprise management system of advanced industrial countries, ERP and MES encountered some difficulties and confusion in the localization process of china. Basing on the characteristics of Chinese process industry and the practical implementation experience of ERP and MES, the new grass-roots production plan model and production control model and accounting model and assessment model and site quality retrospective model and virtual instrument model and etc. is built. And the management system for process-oriented manufacturing industry in China is designed and developed. It is integrated with Chinese manufacturing process of production site characteristics and will be with better reference value.