Paper Title:
The Cyclization of 2-Chloro Nicotinic Acid
  Abstract

Studied the craft of synthesize 2-ChloroNicotinicacid, which was 3-Dimethylamino -acrolein and Eethylcyanoacetate as raw materials, synthesized 2,4-pentadienoicacid-2-cyano-5- dimethylaminoethylester, then used HCl gas to cyclize it, the product Ethyl 2-chloronicotinate was hydrolyzed to get 2-chloronicotinicacid. The effects of solvent and catalyst were discussed. The results showed that 2,4- pentadienoi cacid – 2-cyano-5-(dimethylamino) ethyl ester can be dissolved in dimethylethane at low temperature, so that it avoided the own polymerization when cyclization synthesis Ethyl 2-chloronicotinate. The yield was 91.84%. The craft was simple and had less steps and higher yield; there is the potential for industrialization

  Info
Periodical
Advanced Materials Research (Volumes 233-235)
Edited by
Zhong Cao, Lixian Sun, Xueqiang Cao, Yinghe He
Pages
288-291
DOI
10.4028/www.scientific.net/AMR.233-235.288
Citation
Q. W. Zhang, Y. Cheng, W. Y. Guang, "The Cyclization of 2-Chloro Nicotinic Acid", Advanced Materials Research, Vols. 233-235, pp. 288-291, 2011
Online since
May 2011
Export
Price
$32.00
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