Paper Title:
Synthesis of 2-Chloro-4,6-Diamino-5-Cyanopyrimidine and its Amino-Substituted Derivatives
  Abstract

The important pyrimidine intermediate 2-chloro-4,6-diamino-5-cyanopyrimidine was prepared by the cyclization of sodium salt of 1-amino-1-cyanamino-2,2-dicyanoethylene which was obtained from sodium dicyanamide and malononitrile via the nucleophilic addition in good yield and purity. The 4,6-diamino-5-cyanopyrimidines substituted with different amino groups could be synthesized by nucleophilic substitution reaction of amines, and they have good bactericidal activities to some funguses.

  Info
Periodical
Advanced Materials Research (Volumes 233-235)
Edited by
Zhong Cao, Lixian Sun, Xueqiang Cao, Yinghe He
Pages
321-324
DOI
10.4028/www.scientific.net/AMR.233-235.321
Citation
H. M. Yu, H. F. Li, H. M. Jia, X. H. Zhu, "Synthesis of 2-Chloro-4,6-Diamino-5-Cyanopyrimidine and its Amino-Substituted Derivatives", Advanced Materials Research, Vols. 233-235, pp. 321-324, 2011
Online since
May 2011
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Price
$32.00
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