Paper Title:
A Convenient Method for the Chlorination of P-Methoxybenzyl 2-(3-Phenylacetamido-4-Benzenesulfonylthio-2-Azetidinone-1-Yl)-3-Methyl-3-Butenate
  Abstract

A convenient method for the chlorination of p-methoxybenzyl 2-(3- phenylacetamido-4- benzenesulfonylthio-2-azetidinone-1-yl)-3-methyl-3-butenate from penicillin G with sulfuryl chloride ( SO2Cl2) , which is subsequently converted to p-methoxybenzyl 2-(3- phenylacetamido-4- benzenesulfonylthio-2-azetidinone-1-yl)-3-chloromethyl-3-butenate, versatile intermediates for the synthesis of cephalosporin antibiotics was developed. The method has the advantage of cheap reagents, mild reaction conditions and convenient operation. The quantity and the feeding rate of the chlorination reagent can be controlled easily. The method is particularly suitable for the chlorination in an industral process.

  Info
Periodical
Advanced Materials Research (Volumes 233-235)
Edited by
Zhong Cao, Lixian Sun, Xueqiang Cao, Yinghe He
Pages
66-69
DOI
10.4028/www.scientific.net/AMR.233-235.66
Citation
J. D. Xing, W. L. Wei, H. H. Chang, X. Li, "A Convenient Method for the Chlorination of P-Methoxybenzyl 2-(3-Phenylacetamido-4-Benzenesulfonylthio-2-Azetidinone-1-Yl)-3-Methyl-3-Butenate", Advanced Materials Research, Vols. 233-235, pp. 66-69, 2011
Online since
May 2011
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Price
$32.00
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