Mg-, Zn-, and Cu-substituted aluminophosphate molecular sieves (MeAPO-5 and MeAPO-11) were synthesized by hydrothermal crystallization method. The n-hexane cracking performance over the as-prepared MeAPOs was estimated under different reaction conditions. MeAPO-5 molecular sieves exhibited higher activity for the cracking conversion in the temperature range of 723~823 K than MeAPO-11. The conversion level of n-hexane over MeAPOs with the same topology had the following order: MgAPOs > ZnAPOs > CuAPOs. The cracking results showed that the conversion level of n-hexane increased with increasing reaction temperatures and contact time, and that the first order is determined in the n-hexane concentration.