The mechanism and method were deduced on surface modification of nano-ZnO by titanate coupling agent. EVADPE/ZnO nanocomposite material was prepared, and the tensile strength was tested. Three relatively optimal groups of process parameters were obtained by orthogonal experiment, BP-GA model and BP-PSO model respectively, in which the parameter obtained through BP-GA model was equal to that obtained through BP-PSO model. The iterative times of BP-PSO algorithm were smaller than that of BP-PSO algorithm. With analysis, it was showed that the group of process parameters obtained by BP-GA model and BP-PSO model based on the orthogonal experiment data were much better than that group obtained by orthogonal experiment. The optimal velocity of BP-PSO algorithm was faster than that of BP-PSO model.