Paper Title:
pH-Controlled Drug Release from Mesoporous Silica Spheres with Switchable Gates
  Abstract

Mesoporous silica sphere (MSS) with switchable gates was prepared by the graft of pH-sensitive propyldiethylenetriamine groups (multiamine chains) around mesopore outlets. The textural parameters of the resultant material had been analyzed. In the following test of in vitro drug release, the gated mesoporous material showed high response to solution pH. At high pH (pH 7.5), ibuprofen (IBU) that loaded in this carrier released rapidly and completely (within 2 h); at low pH (pH 4.0 or 5.0), only a small part of the IBU (13 wt%) was slowly released from this carrier and the most of IBU was effectively confined in mesopores.

  Info
Periodical
Advanced Materials Research (Volumes 236-238)
Edited by
Zhong Cao, Yinghe He, Lixian Sun and Xueqiang Cao
Pages
2142-2145
DOI
10.4028/www.scientific.net/AMR.236-238.2142
Citation
Q. Gao, Z. W. Chen, J. Xu, Y. Xu, "pH-Controlled Drug Release from Mesoporous Silica Spheres with Switchable Gates", Advanced Materials Research, Vols. 236-238, pp. 2142-2145, 2011
Online since
May 2011
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Price
$32.00
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