Paper Title:
Optimization of Ullmann Reaction Step in the Synthesis of Sertindole
  Abstract

5-chloro-1-(4- fluorophenyl)-indole is a key intermediate of sertindole. It can be synthesized from 4-fluoro-bromobenzene and 5-chloroindole by Ullmann reaction, but this step required significant optimization to improve yield and reproducibility for the purity processes of the syntheses that have been disclosed are quite complicated and the reaction proceeds usually can’t go to completion. The Ullmann reaction step in the synthesis of sertidole was improved by using purified 5-chloroindole, suitable catalyst and solvent. A viable kilo-scale synthesis of the 5-chloro-1-(4- fluoro phenyl)-indole was described. Simple workup, economical, high yields and purity of product are some advantages of this method.

  Info
Periodical
Advanced Materials Research (Volumes 236-238)
Edited by
Zhong Cao, Yinghe He, Lixian Sun and Xueqiang Cao
Pages
2594-2597
DOI
10.4028/www.scientific.net/AMR.236-238.2594
Citation
W. Li, X. Q. Ma, J. H. Yu, "Optimization of Ullmann Reaction Step in the Synthesis of Sertindole", Advanced Materials Research, Vols. 236-238, pp. 2594-2597, 2011
Online since
May 2011
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Price
$32.00
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