Paper Title:
Inhibition Mechanism and Kinetic Model for Ozagrel on Mushroom Tyrosinase
  Abstract

This investigation shows that ozagrel, an antithrombotic drug, can inhibit mushroom tyrosinase well. The IC50 value was 3.45 mmol/L. Ozagrel was estimated to be a reversible mixed-type inhibitor of mushroom tyrosinase by Lineweaver-Burk plots. The inhibition kinetics has been studied by using the kinetic method of the substrate reaction described by Tsou. The constants of tyrosinase and tyrosinase-substrate complex inhibited by 1.0 mmol/L ozagrel have been determined to be 87.28 and 66.07 µmol/L, respectively.

  Info
Periodical
Advanced Materials Research (Volumes 236-238)
Edited by
Zhong Cao, Yinghe He, Lixian Sun and Xueqiang Cao
Pages
2913-2916
DOI
10.4028/www.scientific.net/AMR.236-238.2913
Citation
B. L. Shu, Y. J. Fan, Q. M. Zhang, Y. L. Liu, Y. Gu, "Inhibition Mechanism and Kinetic Model for Ozagrel on Mushroom Tyrosinase", Advanced Materials Research, Vols. 236-238, pp. 2913-2916, 2011
Online since
May 2011
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$32.00
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