Paper Title:
Preparation and Characterization of Azithromycin-Loaded Nanostructured Lipid Carriers
  Abstract

To function lipophilic drug Azithromycin (AZM) as ophthalmic preparation, Azithromycin-loaded Nanostructured Lipid Carriers (AZM-NLC) were prepared by High Pressure Homogenization (HPH), and its stability was analyzed afterwards. Well-dissolved lipids of Azithromycin were selected, how the ratio of surfactants to lipids influenced the preparation of AZM-NLC was studied, and mature surfactant system was chosen. The optimized ratio of lipid carriers to emulsifiers [ polyoxyethylene (40) stearate - Poloxamer188 (7:3)] in this study was 1:6, and the final drug-capacity rate was 0.5%. Obtained by photon correlation spectroscopy, the mean particle size of AZM-NLC was 76±2 nm. The results showed that AZM-NLC had kept stable for 15 days, and mean particle size increased to 83 nm after four months.

  Info
Periodical
Advanced Materials Research (Volumes 236-238)
Edited by
Zhong Cao, Yinghe He, Lixian Sun and Xueqiang Cao
Pages
2917-2920
DOI
10.4028/www.scientific.net/AMR.236-238.2917
Citation
J. Y. Wu, Q. Xia, "Preparation and Characterization of Azithromycin-Loaded Nanostructured Lipid Carriers", Advanced Materials Research, Vols. 236-238, pp. 2917-2920, 2011
Online since
May 2011
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Price
$32.00
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