Paper Title:
Inclusion Complex of Dibenzoylmethane with β-Cyclodextrin
  Abstract

The inclusion complex of dibenzoylmathane(DBM)with β-cyclodextrin(β-CD)was studied. UV-spectrophotometer was used to investigate the complexation behaviour in liquid medium, and to demonstrate that the DBM aqueous solubility increased 7.27times due to complexation with β-CD and the inclusion rate of DBM was high to 95.92 percent and the drug-loading constant is also high to 37.86ug/g. Solid samples prepared by solution-agitating method. FT-IR was employed to assess the formation of the inclusion complex. Dissolution analysis indicated that dissolution properties of DBM/β-CD complex were superior compared to both pure DBM and the corresponding physical mixture of DBM and β-CD.

  Info
Periodical
Advanced Materials Research (Volumes 239-242)
Edited by
Zhong Cao, Xueqiang Cao, Lixian Sun, Yinghe He
Pages
1879-1882
DOI
10.4028/www.scientific.net/AMR.239-242.1879
Citation
X. Z. Ji, H. J. Liu, L. L. Wang, "Inclusion Complex of Dibenzoylmethane with β-Cyclodextrin", Advanced Materials Research, Vols. 239-242, pp. 1879-1882, 2011
Online since
May 2011
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Price
$32.00
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