Paper Title:
Synthesis and Micellar Properties of Star-Shaped Poly(ε-Caprolactone)-Dextran Amphiphilic Block Copolymer
  Abstract

6-arm star-shaped Poly (ε-caprolactone)-dextran (sPCL-dextran) was synthesized and characterized. The core of the star polymer is dipentaerythritol, the inner block in the arm is hydrophobic poly (ε-caprolactone) (PCL), and the outer block in the arm is hydrophilic dextran. The synthesis involves three steps: (1) The ring-opening polymerization of ε-caprolactone (CL) initiated by dipentaerythritol produces 6-arm star-shaped PCL (sPCL-OH). (2) The sPCL-OH reacts with acryloyl chloride to get star-shaped PCL with acrylate end group (sPCL-CH=CH2). (3) The amino ended dextran (dextran-NH2) is then attached to sPCL-CH=CH2 terminus by Micheal addition to form star-shaped sPCL-dextran. The architecture of products was characterized with 1H NMR, GPC and element analysis. Micellization of sPCL-dextran in aqueous solutions was investigated by DLS. The results showed that the micelle size (Rh) and size distribution are related to the concentration of the sPCL-dextran. Salt, pH value and temperature have no obvious influence on the Rh.

  Info
Periodical
Advanced Materials Research (Volumes 239-242)
Edited by
Zhong Cao, Xueqiang Cao, Lixian Sun, Yinghe He
Pages
2711-2716
DOI
10.4028/www.scientific.net/AMR.239-242.2711
Citation
X. Q. Liu, J. Y. Liu, "Synthesis and Micellar Properties of Star-Shaped Poly(ε-Caprolactone)-Dextran Amphiphilic Block Copolymer", Advanced Materials Research, Vols. 239-242, pp. 2711-2716, 2011
Online since
May 2011
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: He Lei, Guo Liang Zhang
Chapter 1: Chemical Engineering
Abstract:Dextran catches increasing attentions as a drug carrier because of its biocompatibility, biodegradability and ease of modification. In this...
131
Authors: Atthaphon Maneedaeng
Chapter 1: Semiconductors and Nanosystems in Electronics
Abstract:The aim of this study is to develop the synthetic procedure of Zinc Oxide (ZnO) nanoparticles by using surfactant-assisted solvothermal...
43
Authors: Chih Kuang Chen, Wen Jen Lin, Guan You Chen, Yu Te Lin, Rong Siou Jhu, Jia Horng Lin
Chapter 6: Biomaterials and Biomedical Engineering
Abstract:With the advancement of nanotechnology and material chemistry, micelles have emerged as one of the most attractive carriers for anticancer...
433