In situ reaction synthesized TiB reinforced titanium matrix composites were fabricated using rapid non-equilibrium synthesis techniques of laser cladding. Titanium matrix composite were laser cladding treated on Ti-6Al-4V using Ti and B powder mixture, and the designed weight fractions of B were 10 wt.% in the starting powder mixture. The composite coating mainly consists of α-Ti and TiB. The reinforcement TiB is dispersed homogeneously in the composite coating with pre-placed powder thickness of 0.5mm. The influence of pre-placed powder thickness on microstructure of laser cladding coatings was discussed.