This study aims at analyzing the chemical resistance of a wide range additives in air curing ﬂuorocarbon coatings. Scanning Electron Microscope (SEM) and Immersion tests are used to detect coatings performances. The results showed that the surface state of coating does not affect the chemical resistance. While fumed SiO2 content in the coating is lower than 5.2%, chemical resistance are enhanced as the increasing of fumed SiO2 content, then maintained stability as content is more than 5.2%. Chemical resistance is increased gradually while the rutile TiO2 content of coating is less than 3.1%, and essentially unchanged while greater than 3.1%. As wax powder content increases, chemical resistance of coating decreased. Coupling agent content increases, leading to enhanced chemical resistance of the coating when coupling agent content is less than 5.8% and maintained stable while greater than 5.8%. So fumed SiO2, rutile TiO2, and coupling agent would inhance chemical resistance for coating to a certain extent, and wax powder would weaken the chemical resistance.