Mechanical properties of high-rise building on construction and on service life are different. Geometrical model of structure and material property are time-varying on construction, so mechanical property analysis of high-rise building on construction is complex. The software of ANSYS is selected as the analysis tool. Construction process of high-rise building is simulated through the element “life and death” function of ANSYS. Results of analog calculation are close to the actual values of structure because of considering the construction process. It is beneficial to the safety of high-rise building on construction.