In this paper, we report on an analytical solution for beam-type skewed highway bridges subjected to truck loading. To confirm the analysis derivation and the solution obtained, the moment and shear responses to the design truck load are acquired using the analytical method for a number of typical US highway bridges and compared with those from numerical finite element method (FEM) analysis. In addition, the lateral distribution factors for moment and shear used in routine design are investigated based on comparison of the analytical approach and FEM. The analytical solution is shown in good agreement with the FEM result. Furthermore, the relevant provisions in the American Association of State Highway Transportation Officials' (AASHTO's) LRFD Bridge Design Specifications are also discussed here for comparison. It is observed that the design code specified load distribution factor may not predict well, especially for shear and/or severe skew.