The effect of Fly ash (FA) and ground granulated blast-furnace slag (GGBS) on sulfuric acid resistance of concrete has been investigated in this study. Cement was replaced by FA with the incorporation amount from 20% to 50% or by GGBS from 35% to 65%. Results indicate that with an increase in fly ash replacement amount, the sulfuric acid resistance of concrete was improved. Sulfuric acid resistance of concrete with GGBS was improved only when the replacement amount of GGBS exceeds 50%. The basic reason for deterioration of concrete in sulfuric acid is the degradation of C-S-H gel in matrix. Increasing the content of SiO2 in cement paste can improve the acid resistance of concrete.