The interface roughness between pile and rock in rock-socketed pile can influence its bearing mechanism largely. At present the numerical simulation, which simulates the interface roughness with changing the surface shape or interface friction coefficient, is used to study the interface roughness’ influence on pile’s bearing mechanism. It can reveal the pile bearing mechanism in some degree; however, there are some defects and limitations in simulation because of its assumptions and simplifications. Based on the pile foundation of Tian-xing-zhou Bridge, the model test is conducted to study the interface roughness’ influence on rock-socketed pile bearing mechanism. In the model test, the surface of model piles are made different ranging from smooth to rough, and the bed rock is simulated with mixture of sand and plaster, the rock-soil overlain the bed rock is simulated with silty sand, the pile is simulated with organic glass rod according to similarity principle respectively. The results show that load-settlement curves grow more gently, the ultimate bearing capacity is bigger, the proportion of point resistance is lower, and the shaft resistance is bigger which reaches more than 70% of total loading as the surface of pile is rougher. The conclusions are useful to deciding the length of pile foundation in Tian-xing-zhou Bridge.