Due to its better advantages, Double-O-Tube(DOT) shield has been widely applied in shield tunnel construction. But the impact caused by shield tunnel construction on buildings hasn’t been taken seriously. Considering the interaction of building-soil-tunnel, the independent foundation frame building vertical crossed by DOT shield tunnel was simulated by 3D MIDAS/GTS software, and the impact of construction on the building was analyzed. The results show that: during the passage of the shield tunneling through the building, the settlement of the building increased. The settlement was stable and had a little rebound when shield machine already passed the building. The building’s longitudinal displacement was great larger than lateral horizontal displacement. With the increase of driving distance, the first principal stress P1 and maximum shear strain MSmax increased and then were stable. With the increase of L, the first principal stress P1 and maximum shear strain MSmax tended to gradually reduce the security value, and the maximum differential settlement between columns increased first and then decreased. Finally, the safety of the building was assessed comprehensively.