The choice of reasonable parameters of EPB shield tunneling in weathered granite ground is of great importance to reduce tunneling-induced effects on existing tunnels. Combined with the practice of the EPB shield tunneling below existing interval tunnels from Kexueguan station to Dajuyuan station of Shenzhen metro line No.1, the method of design and regulation of main parameters including the earth pressure in excavation chamber, the ground conditioning, the volume of the discharged soil, the grouting control and the advance speed, of the EPB shield tunneling are studied. The practice of the below-crossing shows in the weathered granite ground, it is reasonable that the earth pressure in excavation chamber is taken as 0.15-0.2 mpa, and that FER, FIR and CF of foam are taken as 8-15, 30-50% and 3-5% respectively, and that the amount of synchronization grouting is 8-10 m3 per ring along with the injecting pressure of 0.3-0.4 mpa, and that the second phase injection is employed to control the further settlement of existing tunnels when necessary, and that the advance speed is taken as 8-10 mm/min, and as steady as possible. Meanwhile, adjustments according measured data must be performed when necessary. Moreover, the real-time monitoring and a collaborative-work environment among the Parties involved in project are also very crucial to facilitate the risk management of the below-crossing.