Accurately and quickly evaluate the damage of high-rise buildings can effectively reduce economic losses and speed up the reconstruction of the earthquake region. Based on monitoring data and numerical simulation, this paper proposed a method to evaluate the damage of high-rise structures suffered earthquakes. Taking a frame-tube structure as example, the method’s availability is verified. The results can coincide well with the experimental phenomenon and the fuzzy evaluation results based on the monitoring data. This method can accurately and effectively evaluate the general damage degree of high-rise structures post-earthquake.