In this paper, different types of steel frame structure under earthquake are adopted as the analyzed object of structural collapse. Seismic waves can be applyed into the structure in form of dynamic acceleration in ANSYS/LS-DYNA. The whole process of earthquake effects on the structure is simulated truly. It is helpful to realize and understand the failure mechanism and space mechanism of the different forms of steel frame structures. This paper can also provide a reference for reinforcement and maintenance of structure and a basis of anti-seism design of structure.