With the constant expansion of higher education and a large scale of construction of educational buildings in recent years, the consideration of how to design a space which can play a role in promoting innovative research was relatively static. Most of designs often simply use the same principle of commercial buildings and office buildings. It often shows a sign of empiricism in the organization of teaching spaces, which is lack of scientific research of spatial framework based on knowledge. Therefore it is difficult to achieve the impetus for the creativity of space designs. The aim of this paper is to put forward the space quality factor for promoting random exchange, and the application of strategy for the design of the actual teaching space based on the scientific research of space design and creativity. It also consequently transfers the colleges and universities teaching space to a real high quality environment where creativity can be motivated, in order to promoting the training of creative talents.