Nacre of molluscan shells is famous for its “brick and mortar” microstructure and possesses excellent mechanical properties. Three-point bending strengths of nacre parallel and vertical to the surfaces of platelets are tested and the different fracture surfaces were characterized. The result shows that the values of three-point bending strength in the two directions are approximately the same. Base on the microstructure of and toughening mechanism of nacre, the inspiration for architecture was put forward as follows: to redesign the building materials, toughen the architecture in several ways, and enhance the properties of architecture in all directions. The aim of the paper is to call out learning from nacre to create novel architecture and building materials.