A steel reinforced concrete frame-concrete core wall structure is taken as the research object in this paper. The whole space finite element models are established by software ETABS, modal analysis, response spectrum method and elastic time-history analysis are conducted. And static elastio-plastic time history analysis of the high-rise structure is conducted by software MIDAS/GEN. Seismic response of the high-rise structure is analyzed under medium earthquake and rare earthquake , elastic deformation is calculated under conventional earthquake and elastic-plastic deformation is calculated under rare earthquake. The results show that the structure can meet the requirements of no-damage under light earthquake, repairable under medium earthquake and no-collapse under strong earthquake.