The failure of the reinforced concrete (RC) column on the ground floor may result in progressive collapse of the whole building. In the paper, the finite element program LS-DYNA is used to simulate the dynamic response of RC column with different constraints subjected to blast pressure. A three dimensional solid model is established for the RC column. A brittle damage model is applied to simulate the concrete. The lateral displacement and failure mode of RC column with different scaled distances are investigated and discussed. It can be found that the pressure nephogram and x-direction displacement of fixed end column under different scaled distance have the obvious symmetry. Moreover, both the maximum pressure and x-direction displacement of one end fixed and one end simply supported column are bigger than fixed end column with the same scaled distance.