Beijing subway Huangzhuang stations is cross-transfer station. It has a complex tunneling structure. The characteristics of the reverse construction vertical well was been thinking in the course of excavation design. The vertical well excavation and support method, horizontal wells channel excavation and support methods, the main station pilot tunnel excavation and support methods were researched to determine in detail. In order to analysis and evaluation the feasibility of excavation and getting into hole, FLAC3D numerical simulation analysis method was applied to do simulation of the vertical well, horizontal channel and the main cavern excavation. All detail construction course of these three-part were been studied. Excavation and supporting method and progress were all included. The ground surface subsidence, deformation of support structure and strengthen structure were been got. On the condition of the vertical well support structure destruction caused by the horizontal guide hole excavation and the group cave effect caused by guiding cave excavation in main station underground building, the support structure and ground soil stability were studied. The research result gave the base technical support for the project optimization design and construction security.