Sanmashan side slope in the Three Gorges reservoir region is located in the center area of the Xincheng district, Fengjie county, China. Based on the analysis of hydrogeological structure of the studied area, one can conclude that a groundwater reservoir form near the side slope area after the impoundment of the Three Gorges Reservoir, which induces large groundwater pressure on the side slope. In particular, large hydrodynamic pressure will occur in the landslide mass under the condition of the reservoir water level descending significantly, which has bad effects on slope stability. Numerical simulation results show that the seepage force on landslide is 43 times of that under normal situation, as the reservoir water level declining dramatically from 175m to 145m. Thus, the influence of hydrodynamic pressure should be considered in the stability calculation.